Researching complex interventions in nursing

The REFLECTION Network is
leading translational nursing intervention research in Europe

Goals of the REFLECTION Network

  • spot 1Develop an interdisciplinary European Faculty network of researchers in nursing, equipped to design, plan and implement programmatic, mixed methods and complex interventions research in nursing
  • Spot 2Share knowledge and expertise in advanced translational complex interventions research methods in nursing, by running summer schools for the new generation of early stage researchers in Europe taught by leaders in the application of complex translational research methods
  • Spot 3Develop programmes of translational research in nursing which are multi-state, multi-disciplinary, and directed at improving the evidence base of nursing to meet European health and social care concerns

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Clenbuterol Induces Cell Cycle Arrest In C2C12 Myoblasts By Delaying P27 Degradation Through Β-arrestin 2 Signaling

Abstract

The study investigated the mechanism by which Clenbuterol induces cell cycle arrest in C2C12 myoblasts. Findings demonstrated that Clenbuterol delays the degradation of p27, a critical cyclin-dependent kinase inhibitor, through modulation of β-arrestin 2 signaling pathways. This delay in p27 turnover contributes to the observed cell cycle arrest, highlighting a novel role for β-arrestin 2 in regulating myoblast proliferation. The results provide insights into the molecular basis of Clenbuterol cycle effects on muscle cells and underscore the interplay between receptor signaling and cell cycle regulation.

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